本试验采用正交设计，在不同的药物处理，疗程、剂量和感染时间等多种因素作用下，以感染率，囊重（抑制率），囊数及包虫囊病理改变为评价指标，观察了联合应用阿苯达唑（Ａｌｂ）与吡喹酮（Ｐｒａ）治疗小鼠腹腔感染的原头节及包虫囊的效果。结果表明：联合用药无论对感染的原头节还是发育的包虫囊均有明显疗效，优于单一用药，而且在原头节感染早期用药的效果较优，这一结果对临床化疗有一定意义。 In this study, the orthogonal design was used to evaluate the pathological changes of infection rate, weight (inhibition rate), number of cysts and hydatid cyst with different factors such as drug treatment, duration of treatment, dose and infection time. The combination of albendazole (Alb) and praziquantel (Pra) in the treatment of abdominal infection of the original mouse head and hydatid effect. The results showed that the combination therapy had obvious curative effect on hydatid cyst infected or not, which was better than single treatment and better effect in the early infection of protoscoleces. This result has some significance to clinical chemotherapy.