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目的:观察大黄对实验性癫痫的防治作用,为借助古代方剂文献获取的大黄“息风止痉”潜在功能提供客观依据。方法:采用最大电惊厥(MES)、戊四唑、士的宁等化学性癫痫模型,给予大黄1g/kg、2g/kg、4g/kg每日1次灌胃,观察动物的惊厥发作次数、发作潜伏期及动物存活时间以及脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)活性的影响。结果:大黄可减少MES发作次数,延长戊四唑、士的宁所致小鼠惊厥的潜伏期,延长戊四唑癫痫大鼠发作潜伏期,提高脑组织SOD、GSH-PX活性,降低MDA水平。结论:大黄可以对抗小鼠MES、戊四唑和士的宁等化学性惊厥及癫痫大鼠脑组织氧化,对癫痫有一定的防治作用,为确认其“息风止痉”功用提供了客观依据。
OBJECTIVE: To observe the preventive and therapeutic effects of rhubarb on experimental epilepsy and to provide objective evidence for the potential functions of rhubarb “Bifengzhie” obtained from ancient prescriptions. Methods: The largest epilepsy (MES), pentylenetetrazol, strychnine and other chemical epilepsy models were given to rhubarb 1g/kg, 2g/kg, 4g/kg gavage once a day to observe the number of seizures in animals, Incidence latency, animal survival time, and the effects of superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-PX) activity in brain tissue. Results: Rhubarb can reduce the number of episodes of MES, prolong the latency of convulsions induced by pentylenetetrazol and strychnine in rats, prolong the incubation period of pentylenetetrazol epilepsy in rats, increase the activity of SOD and GSH-PX in brain and decrease the level of MDA. Conclusion: Rhubarb can antagonize the brain oxidation of mice with chemical convulsions and epilepsy induced by mouse MES, pentylenetetrazol and strychnine, and has certain preventive and therapeutic effects on epilepsy. Objective basis.