论文部分内容阅读
目的观察不同疗程磺达肝癸钠治疗非ST段抬高型心肌梗死(NSTEMI)的有效性和安全性。方法采用前瞻性随机对照研究,入选收住我院心内科确诊的NSTEMI患者共221例,随机分为短疗程组(110例)和长疗程组(111例),两组均给予常规基础药物治疗。短疗程组给予磺达肝癸钠一日2.5 mg,持续3 d;长疗程组给予磺达肝癸钠一日2.5 mg,持续7 d。观察治疗30 d内两组主要不良心血管事件的发生情况,包括心源性死亡、非致死性再次心肌梗死、靶器官再次血运重建及再发心绞痛例数,同时统计两组出血发生率及治疗前后血小板计数。结果两组心源性死亡、非致死性再次心肌梗死、靶器官再次血运重建及再发心绞痛发生率比较,组间差异无统计学意义(P>0.05)。两组治疗前后血小板计数比较,差异无统计学意义(P>0.05)。两组均无严重出血事件发生,但短疗程组出血发生率明显低于长疗程组(P<0.05)。结论磺达肝癸钠治疗NSTEMI,3 d疗程的有效性不劣于7 d疗程。同时,短疗程组的出血事件较长疗程组少,安全性更高。
Objective To observe the efficacy and safety of fondaparinux in treatment of non-ST-segment elevation myocardial infarction (NSTEMI). Methods 221 prospective randomized controlled trials were enrolled and 221 patients with NSTEMI admitted to our hospital were randomly divided into a short course of treatment (110 cases) and a long course of treatment (111 cases). Both groups were given conventional basic medical treatment . The short course of treatment was given fondaparinux 2.5 mg on the 1st, for 3 days; long course of treatment given fondaparinux 2.5 mg for 7 days. The incidence of major adverse cardiovascular events, including cardiac death, non-fatal myocardial infarction, target organ revascularization and angina recurrence within 30 days after treatment, were observed. The incidence of hemorrhage in both groups and Platelet count before and after treatment. Results There was no significant difference between the two groups in the incidence of cardiac death, non-fatal myocardial infarction, revascularization of target organs and recurrence of angina. There was no significant difference between the two groups (P> 0.05). There was no significant difference in platelet count between the two groups before and after treatment (P> 0.05). No severe bleeding occurred in both groups, but the incidence of hemorrhage in the short course group was significantly lower than that in the long course group (P <0.05). Conclusion Fondaparinux treatment of NSTEMI, 3 d course of treatment is not less than 7 d course of treatment. At the same time, shorter courses of bleeding episodes longer courses, safety is higher.