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目的探讨血液净化患者口服及静脉给予铁剂后短期临床疗效。方法选取洛阳市第三人民医院血液净化科长期规律透析患者50例,均常规应用促红素,随机分为两组,每组25例,A组静脉使用蔗糖铁,B组口服琥珀酸亚铁。治疗前后分别检测红细胞(RBC)、血红蛋白(Hb)、红细胞压积(HCT)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)、门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血尿素氮、肌酐及观察临床症状的改变。结果两组在治疗后对比BUN、Cr、AST的数值无明显变化,ALT轻度升高,但差异无统计学意义(P>0.05);治疗后对比RBC、Hb、HCT、SF、TSAT数值,静脉给予铁剂组明显高于口服给予铁剂组,差异具有统计学意义(P<0.05)。结论血液净化患者静脉补铁可使SF和TSAT显著改善,Hb及HCT明显升高。
Objective To investigate the short-term clinical efficacy of oral and intravenous iron administration in blood purification patients. Methods 50 patients with long-term hemodialysis patients in Luoyang Third People’s Hospital were enrolled. All of them were routinely treated with erythropoietin and were randomly divided into two groups (n = 25 in each group). Group A received sucrose iron intravenously and group B received oral administration of ferrous succinate . The levels of RBC, Hb, HCT, SF, TSAT, AST, Acid aminotransferase (ALT), blood urea nitrogen, creatinine and observation of clinical symptoms. Results After treatment, there was no significant difference in the values of BUN, Cr and AST between the two groups, and ALT was slightly increased (P> 0.05). After treatment, the values of RBC, Hb, HCT, Intravenous administration of iron was significantly higher than that of oral administration of iron, the difference was statistically significant (P <0.05). Conclusion Intravenous iron supplementation in patients with blood purification can significantly improve the SF and TSAT, Hb and HCT was significantly increased.