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本文采用聚乙二醇沉淀-补体消耗法测定了92例不同类型肾小球疾病患儿的循环免疫复合物(CIC)。在各类肾小球疾病中急性感染后肾炎(APGN)患儿的CIC阳性率(27/34)及血清水平均最高,且与APGN的疾病活动性有关。13例患上呼吸道感染的患儿(无肾小球疾病)中4例CIC阳性。APGN患儿的CIC持续时间明显长于上呼吸道感染患儿。12例患儿做了肾穿刺活检,其中7例肾小球证明有免疫复合物沉积的病例中4例CIC阳性,而5例肾小球无免疫复合物沉积的病例中仅1例CIC阳性。
In this paper, circulating immunocomplex (CIC) was measured in 92 children with different types of glomerular diseases using polyethylene glycol precipitation-complement depletion assay. CIC positive rate (27/34) and serum level of children with acute post-infection nephritis (APGN) were the highest in all kinds of glomerular diseases and were related to the disease activity of APGN. Of the 13 children with respiratory tract infection (no glomerular disease), 4 were positive for CIC. The duration of CIC in children with APGN was significantly longer than that in children with upper respiratory tract infection. Of the 12 children who underwent kidney biopsy, 4 of the 4 patients with glomerular glomerular deposition of immunocomplex showed positive CIC, whereas only 1 of the 5 patients with glomerular immune complex deposited was positive for CIC.