论文部分内容阅读
HIV-1的全面多样性意味着开发HIV-1疫苗面临着巨大的困难,常见的情况是所开发的疫苗产生的抗体只能对抗易中和的病毒(easy-to-neutralize virus),而对难中和的病毒(difficult-to-neutralize virus)无能为力。HIV-1镶嵌抗原是根据生物信息学优化设计的免疫原,能改善对HIV-1多样性的覆盖率,然而,至今此类全面性疫苗还没有成功的报道。美以科学家最近的一项工作发现,用基于腺病毒/痘病毒和腺病毒/腺病毒为载体制备的、表达二价镶嵌HIV-1蛋白Env/Gag/Pol免疫原的疫苗对
The full diversity of HIV-1 means that developing HIV-1 vaccines presents a huge challenge. Commonly, the developed vaccines produce antibodies that are resistant to easy-to-neutralize viruses, Difficult-to-neutralize virus is powerless. HIV-1 mosaic antigen is an immunogen optimized based on bioinformatics, which can improve the coverage of HIV-1 diversity. However, no such comprehensive vaccine has been reported so far. A recent work by scientists on the United States found that vaccine pairs that express Env / Gag / Pol immunogen bivalent mosaic HIV-1 protein prepared using adenovirus / poxvirus and adenovirus / adenovirus as vectors