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目的:血吸虫病是否为大肠癌的一种癌前病变多年来一直存在不同意见,本文探讨血吸虫病与大肠癌的关系.方法:应用流式细胞术检测大肠慢性血吸虫病及大肠癌细胞DNA含量及两种癌基因表达产物(p21~ras,p~53蛋白)的变化.结果:42例大肠慢性血吸虫病患者(包括24例单纯血吸虫病和18例伴虫卵息肉者)的细胞DNA含量及两种癌基因产物表达均无明显异常,而12例伴血吸虫病的大肠癌与11例单纯大肠癌及其癌周粘膜在以上两方面亦未显示出明显差异.结论:本组资料未能表明慢性血吸虫病肠道病变作为癌前病变可能具有的恶性转化特性,从而不支持血吸虫病与大肠癌之间的直接因果联系,提示二者很可能为一种伴存关系.
Objective: Whether schistosomiasis is a precancerous lesion of colorectal cancer has been different opinions for many years. This article discusses the relationship between schistosomiasis and colorectal cancer. Methods: Application of flow cytometry to detect DNA content in chronic schistosomiasis and colorectal cancer cells. Changes of two oncogene expression products (p21~ras, p~53 protein). Results: Cell DNA content in 42 patients with chronic schistosomiasis of the large intestine (24 cases of schistosomiasis alone and 18 cases of egg polyps) and two No significant abnormalities were observed in the expression of the oncogene gene products, while 12 cases of colorectal cancer associated with schistosomiasis and 11 cases of colorectal cancer and its pericancerous mucosa did not show any significant differences in the above two aspects. Conclusion: The data in this group did not indicate chronicity. Schistosomiasis intestinal lesions may have malignant transformation characteristics as precancerous lesions, and thus do not support the direct causal link between schistosomiasis and colorectal cancer, suggesting that the two are likely to be a kind of associative relationship.