临床上药物性红皮病并肾损害报导极少,现报告二例如下: 例1,男性,53岁。因高热肌注复方氨基比林后,全身皮肤红肿,部分里出血性皮疹或脱屑。多次尿蛋白(±),Bun、IgA、IgM等均正常,IgG2746mg%,C_3 0.56 mg/ml。拟药物性红皮病。初用Dexamethasone 10～15mg/d,静滴,20天后改pred-nisone 30mg/d,皮疹进行性加重,呈干燥性片状脱屑,进行性尿少,Bun 23.21 mmol/L,Cr 964.2μ Clinically, drug-induced erythroderma and renal damage reported very few reports are as follows: Example 1, male, 53 years old. Due to hyperthermic intramuscular injection of compound aminopyrine, systemic skin irritation, hemorrhagic rash or scaling. Repeated urinary protein (±), Bun, IgA, IgM, etc. were normal, IgG2746mg%, C_3 0.56 mg / ml. Proposed drug-induced erythroderma. Initial use of Dexamethasone 10 ~ 15mg / d, intravenous drip, 20 days later pred-nisone 30mg / d, rash progressive increase was dry flaky scaling, progressive oliguria, Bun 23.21 mmol / L, Cr 964.2μ