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细菌耐药性的获得和传播主要与整合子-基因盒系统有关。它在细菌中捕获外来耐药基因水平传递,从而在整合子中形成多种耐药基因的组合和排列,是细菌耐药性传播的机制之一。一个整合子可捕获一个或多个基因盒,组成多重耐药整合子,介导细菌的耐药性。携带重组基因盒的整合子能插入到转座子或接合性质粒中,在细菌中传播耐药性并通过位点特异的基因重组使耐药基因发生播散,它对细菌间耐药基因的扩散和多重耐药性的产生起到重要作用。
The acquisition and spread of bacterial resistance is mainly associated with the integron-gene cassette system. It traps the transfer of foreign drug resistance genes in bacteria and thus forms a combination and arrangement of multiple resistance genes in the integron, which is one of the mechanisms of bacterial resistance spread. An integron can capture one or more gene cassettes, forming multiple drug resistance integrons, mediating bacterial resistance. Integrons that carry recombinant gene cassettes can be inserted into transposons or conjugative plasmids, propagating resistance in bacteria and disseminating drug resistance genes through site-specific genetic recombination, Diffusion and multi-drug resistance play an important role.