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胃癌是我国常见的恶性肿瘤之一,死亡率高。早期胃癌手术治疗效果最好,但我国收治的胃癌患者以中晚期为多,单纯手术疗效不如综合治疗,以化疗为主的综合治疗是常用的重要治疗手段。以前曾认为胃癌对化疗的敏感性较低,化疗药单药有效率多在10～20％之间。随着临床研究的深入及新化疗药的出现,胃癌的化疗有效率大为提高,无论是胃癌的辅助治疗还是姑息治疗,都取得了较好的临床疗效。其中5—FU仍是治疗胃腺癌的主要化疗药物。 1 胃癌的术前辅助化疗 术前辅助化疗又称新辅助化疗(Neoadjuvantchemotherapy),在胃癌周围血管和淋巴管尚未被手术破坏且全身状况较好之前进行化疗,以使临床分
Gastric cancer is one of the most common malignancies in China and has a high mortality rate. The surgical treatment of early gastric cancer has the best effect. However, the gastric cancer patients treated in our country are mostly middle and late, and the efficacy of simple surgery is not as comprehensive as comprehensive treatment. Comprehensive treatment based on chemotherapy is an important and commonly used treatment method. It was previously thought that the sensitivity of gastric cancer to chemotherapy was low, and the single-agent efficiency of chemotherapy drugs was between 10 and 20%. With the deepening of clinical research and the emergence of new chemotherapeutics, the efficiency of chemotherapy for gastric cancer has been greatly improved. Whether gastric cancer is adjuvant therapy or palliative treatment, good clinical efficacy has been achieved. Among them, 5-FU is still the main chemotherapy drug for gastric adenocarcinoma. 1 Preoperative adjuvant chemotherapy for gastric cancer Preoperative adjuvant chemotherapy, also known as neoadjuvant chemotherapy, involves chemotherapy before the peripheral blood vessels and lymphatic vessels of the gastric cancer have been surgically destroyed and the whole body is in good condition.