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目的：为临床癫痫患者丙戊酸的合理用药提供参考。方法：采用荧光偏振免疫法对１２３ 例癫痫患者进行血药浓度监测，并对其结果及疗效进行分析总结。结果：达到丙戊酸有效血药浓度范围未有效控制的有１４ 例，占１１－４ ％ ；不在有效血药浓度范围而控制良好的有１１ 例，占８－９ ％ 。结论：丙戊酸的个体化给药必须综合考虑各方面的因素，不能仅仅以血药浓度为依据，并建议在适当情况下有必要监测游离丙戊酸血药浓度。
Objective: To provide a reference for rational use of valproic acid in patients with clinical epilepsy. Methods: The plasma concentration of 123 epileptic patients was monitored by fluorescence polarization immunoassay, and its results and therapeutic effects were analyzed and summarized. Results: The effective plasma concentration of valproic acid was not effectively controlled in 14 cases, accounting for 11-4%; not in the effective blood concentration range and well-controlled in 11 cases, accounting for 8-9%. CONCLUSIONS: Individualized administration of valproic acid must take various factors into consideration and can not be based solely on plasma concentrations, and suggests that it is necessary to monitor free valproic acid plasma concentrations where appropriate.