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目的评价晚蚕沙外熨联合来氟米特治疗类风湿关节炎肿痛的临床疗效和安全性。方法采用随机、单盲对照法将60例类风湿关节炎患者随机分为治疗组和对照组。治疗组应用晚蚕沙外熨联合来氟米特口服,对照组应用布洛芬缓释胶囊联合来氟米特口服。2组疗程均为12周,比较治疗前后中医症状积分及实验室指标的改变,并评估其安全性。结果治疗组显效率为83.37%,对照组为44.83%,组间比较差异无统计学意义(P>0.05)。治疗组在减少关节肿胀、晨僵方面疗效明显优于对照组(P<0.05)。2组患者治疗后类风湿因子、红细胞沉降率及C反应蛋白等指标较治疗前均明显改善(P<0.05),但组间比较差异无统计学意义(P>0.05)。治疗组不良反应明显少于对照组(P<0.05)。结论晚蚕沙外熨联合来氟米特治疗类风湿关节炎可有效缓解患者临床症状和体征,改善实验室指标,并可减少不良反应。
Objective To evaluate the clinical efficacy and safety of external application of levofloxacin combined with leflunomide in the treatment of rheumatoid arthritis and sore throat. Methods Sixty patients with rheumatoid arthritis were randomly divided into treatment group and control group by randomized, single-blind control. In the treatment group, the late silkworm excrement combined with leflunomide was administered orally, while the control group was given ibuprofen sustained release capsules combined with leflunomide. The two courses of treatment were 12 weeks, before and after treatment to compare TCM symptom scores and laboratory indicators, and assess its safety. Results The effective rate was 83.37% in the treatment group and 44.83% in the control group. There was no significant difference between the two groups (P> 0.05). The treatment group was significantly better than the control group in reducing joint swelling and morning stiffness (P <0.05). After treatment, the indexes of rheumatoid factor, erythrocyte sedimentation rate and C-reactive protein in two groups were significantly improved after treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). Adverse reactions in the treatment group were significantly less than those in the control group (P <0.05). Conclusion Latex silkworm sand combined with leflunomide treatment of rheumatoid arthritis can effectively alleviate the clinical symptoms and signs of patients, improve laboratory indicators, and reduce adverse reactions.