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应用放射配基结合分析法检测３１例肝细胞癌（ＨＣＣ）及癌旁组织中雄激素受体（ＡＲ）的改变。结果ＨＣＣ癌组织中ＡＲ含量为２５０．３６±１１０．４５ｆｍｏｌ／ｍｇ·Ｐ，癌旁组织中ＡＲ含量为９０．５５±３１．５６ｆｍｏｌ／ｍｇ·Ｐ，ＨＣＣ癌组织中ＡＲ明显高于癌旁组织（Ｐ＜０．０１）。ＡＲ含量与血清甲胎球蛋白（ＡＦＰ）、Ｂ型肝炎携带情况及ＨＣＣ组织学类型无相关性（Ｐ＞０．０５）。ＡＲ含量的增加可能与肝细胞的癌变有关，ＡＲ可能促进ＨＣＣ的产生和发展，部分ＨＣＣ具有雄激素依赖性，为ＨＣＣ可能的抗雄激素治疗提供了依据。
Radioligand binding assay was used to detect the change of androgen receptor (AR) in 31 cases of hepatocellular carcinoma (HCC) and adjacent tissues. Results The AR content in HCC tissues was 250.36±110.45 fmol/mg·P, and the AR content in adjacent tissues was 90.55±31.56 fmol/mg·P. The AR in HCC tissues was significantly higher than that in adjacent tissues. (P<0.01). There was no correlation between AR content and serum alpha fetoprotein (AFP), hepatitis B carrier status and histological type of HCC (P>0.05). The increase of AR content may be related to the carcinogenesis of hepatocytes. AR may promote the generation and development of HCC. Some HCCs are androgen-dependent, providing a basis for possible anti-androgen treatment of HCC.