据统计,目前中国每年2000万新生儿中,出生缺陷儿童总数高达80万至120万人,占每年出生人口总数的4%～6%。出生缺陷不仅是围产儿和婴幼儿死亡的主要死因,也是导致儿童和成人残疾的主要原因,出生缺陷给家庭和社会带来了沉重的精神和经济负担。预防出生缺陷,降低出生缺陷的发生率,已经成为现代产科的研究方向和重大挑战。 According to statistics, among the 20 million newborns in China each year, the total number of children born with disabilities is as high as 800,000 to 1,200,000, accounting for 4% to 6% of the total number of births each year. Birth defects are not only the leading cause of death in perinatal and infants but also the leading cause of disability in children and adults. Birth defects have brought heavy mental and financial burdens to families and society. Prevention of birth defects, reduce the incidence of birth defects, has become the research direction and major challenge of modern obstetrics.