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在热板诱发的小鼠疼痛试验中，血浆丙二醒（MDA）含量显著增高，连续二次致痛，MDA含量增高更明显；在扭体试验中，小鼠脑组织、血浆及腹腔灌洗液中MDA含量均有显著增高。sc吗啡5mg／kg可以显著抑制MDA含量的增加；在热板和扭体致小鼠疼痛中，血浆超氧化物歧化酶（SOD）和谷肽甘肽过氧化物酶（GSH－PX）的活性也有显著增强。实验结果提示在疼痛过程中，MDA含量有显著增高，同时体内抗氧化能力也有显著的提高。
In the hot-plate-induced mouse pain test, plasma propidium oxide (MDA) content was significantly increased, continuous secondary pain, MDA content increased more obvious; writhing test in mice brain tissue, plasma and abdominal lavage MDA content in liquid significantly increased. Sc morphine 5mg / kg can significantly inhibit the increase of MDA content; in the hot plate and writhing mice pain, plasma superoxide dismutase (SOD) and glutathione glycogen peroxidase (GSH-PX) activity Also significantly enhanced. The experimental results suggest that during the pain process, the content of MDA is significantly increased, meanwhile, the antioxidant capacity in vivo is significantly improved.