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目的探讨钙粘素E（E-cadherin）在膀胱移行细胞癌中的表达及临床意义。方法应用免疫组织化学方法对59例膀胱移行细胞癌中钙粘素E的表达进行研究。结果59例膀胱移行细胞癌中34例出现钙粘素E表达异常（5763%），其异常表达率在肿瘤病理分级、临床分期等方面具有显著性差异（P＜0.05）。结论钙粘素E的表达异常与膀胱肿瘤的恶性进展有关，可作为判断肿瘤复发及预后的指标。
Objective To investigate the expression of E-cadherin in bladder transitional cell carcinoma and its clinical significance. Methods The expression of cadherin E in 59 cases of bladder transitional cell carcinoma was studied by immunohistochemistry. Results The expression of cadherin E was abnormal in 34 cases of 59 cases of transitional cell carcinoma of the bladder (5763%). The abnormal expression rate was significantly different (P <0.05) in tumor pathological grade and clinical stage. Conclusions The abnormal expression of cadherin E is related to the malignant progression of bladder neoplasm, which may be used as an indicator of tumor recurrence and prognosis.