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目的研究尿激酶型纤溶酶原激活剂(uPA)及其受体(uPAR)在人肺癌中的表达及其与肺癌临床病理特征的关系。方法通过免疫组织化学方法检测101例肺癌组织及7例正常肺组织中uPA、uPAR的表达情况,利用CMIAS2000型多功能真彩病理图像分析系统测量计算各病例中uPA、uPAR蛋白阳性细胞的平均光密度(AOD)和积分光密度(IOD)。结果 uPA、uPAR在肺癌组织中表达的阳性率高于正常肺组织,二者在非小细胞肺癌(NSCLC)的表达强于小细胞肺癌(SCLC)但均不具有显著性差异;二者在不同组织学类型、不同分期肺癌中的表达均不具有显著性差异;uPAR与肺癌分级呈显著正相关;uPA、uPAR与肺癌淋巴结转移密切相关,与合并分期显著正相关;二者之间均存在显著正相关关系。结论 uPA、uPAR参与肺癌侵袭转移,且二者具有协同作用。
Objective To investigate the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human lung cancer and its relationship with the clinicopathological features of lung cancer. Methods The expression of uPA and uPAR in 101 lung cancer tissues and 7 normal lung tissues was detected by immunohistochemical method. The average light intensity of uPA and uPAR protein positive cells in each case was measured and measured by CMIAS2000 multi-function true color pathological image analysis system Density (AOD) and Integral Optical Density (IOD). Results The positive rates of uPA and uPAR expression in lung cancer tissues were higher than those in normal lung tissues. The expressions of uPAR and uPAR in non-small cell lung cancer (NSCLC) were stronger than those in small cell lung cancer (SCLC), but not significantly different There was no significant difference in histological type and stage of lung cancer, uPAR and uPAR were positively correlated with lung cancer grade, uPA and uPAR were closely related to lymph node metastasis of lung cancer, and were significantly and positively correlated with the stage of lung cancer Positive relationship. Conclusion uPA and uPAR participate in the invasion and metastasis of lung cancer, and both have synergistic effects.