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目的 探讨一氧化氮(NO)与妊娠期肝内胆汁瘀积(ICP)并胎儿窘迫(胎窘)的关系。方法 采用硝酸根还原酶与Griess反应相结合的方法,测定40例正常晚期妊娠妇女(晚孕组)、36例无胎窘ICP孕妇(ICP组)、33例ICP并胎窘(胎窘组)孕妇静脉血及脐血中NO代谢产物亚硝酸基/硝酸基(NO2-/NO3-)进行测定。结果 胎窘组母血NO2- /NO3-含量显著低于另两组(P <0.01);胎窘组脐血NO2-/NO3-水平显著低于晚孕组及ICP组(P<0.01);脐血NO2-/NO3-水平与pH、PO2呈显著正相关,与PCO2呈显著负相关(P<0.01)。结论NO含量的降低是导致ICP患儿发生胎窘的一个重要因素。
Objective To investigate the relationship between nitric oxide (NO) and intrahepatic cholestasis of pregnancy (ICP) and fetal distress (fetal distress). Methods Forty normal pregnant women (late pregnant group), 36 pregnant women without ICP (ICP group), 33 pregnant women with ICP and fetal distress were enrolled in this study. Venous blood of pregnant women and NO metabolites nitrite / nitrite (NO2- / NO3-) in cord blood were measured. Results The levels of NO2- / NO3- in maternal blood in fetal distress group were significantly lower than those in the other two groups (P <0.01). The levels of NO2- / NO3- in umbilical cord blood in fetal distress group were significantly lower than those in late pregnancy group and ICP group (P <0.01). The level of NO2- / NO3- in umbilical cord blood was positively correlated with pH and PO2, and negatively correlated with PCO2 (P <0.01). Conclusion The decrease of NO content is an important factor leading to fetal embolism in children with ICP.