Background. Extrauterine lipoleiomyomas are an uncommon finding, especially in the preperitoneum. These benign tumors have been attributed to seeding after su rgical fibroid resection, exogenous hormonal therapy, or major disturbances in g lucose metabolism. Case. We are reporting the case of a postmenopausal woman wit hout any history of gynecological surgery, hormonal therapy, or significant meta bolic abnormality who developed a large, symptomatic, preperitoneal lipoleiomyom a requiring resection. The patient had an uneventful recovery with full resoluti on of her symptoms. Conclusion. Our case relates the first description to our kn owledge of the de novo growth of a large lipoleiomyoma in an incisional umbilica l scar independent of gynecological pathology or hormonal influence. Background. Extrauterine lipoleiomyomas are an uncommon finding, especially in the preperitoneum. These benign tumors have been attributed to seeding after su rgical fibroid resection, exogenous hormonal therapy, or major disturbances in g lucose metabolism. Case. We are reporting the case of a postmenopausal woman wit hout any history of gynecological surgery, or significant meta bolic abnormal who who developed a large, symptomatic, preperitoneal lipoleiomyom a requiring resection. Conclusion: Our patient had an uneventful recovery with full resoluti on of her symptoms. Conclusion. Our case first description to our kn owledge of the de novo growth of a large lipoleiomyoma in an incisional umbilica l scar independent of gynecological pathology or hormonal influence.