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长期滥用解热镇痛剂会引起尿路癌。长期滥用含非那西汀、阿司匹林、安替比林、咖啡因等药物的病人,其肾脏常受到损害,如发生肾乳头坏死、非阻塞性肾炎等。发生上述肾脏病变的病人其肾盂癌及膀胱癌的发生率很高:一股慢性肾病病人其肾盂癌的发生率为0.7%,而长期滥用上述解热镇痛剂者则约为9.5%。发生尿路癌的病人,滥用该类药的时间,为数年至30年。雌激素是否致癌?雌激素是常用的女用口服避孕药的一种成分,女性生殖系统的多种疾病亦用雌激素治疗,因此查明它是否致癌十分重要。大量动物实验证明,肿瘤自然发生率高的小鼠,饲喂雌激素可使雄鼠的肿瘤发生率增高,但对雌鼠无作用。
Long-term abuse of anti-inflammatory drugs can cause urinary tract cancer. Long-term abuse of phenacetin, aspirin, antipyrine, caffeine and other drugs in patients with their kidneys often suffer damage, such as the occurrence of renal papillary necrosis, non-obstructive nephritis. The incidence of renal pelvis and bladder cancer is high in patients with the above kidney disease: 0.7% of patients with renal pelvis cancer are found in a chronic kidney disease and 9.5% are those who have long been abusing the above antipyretic and analgesic agents. Urinary tract cancer patients, the abuse of such drugs for a few years to 30 years. Is estrogen carcinogenic? Estrogen is a commonly used female oral contraceptives, a variety of diseases of the female reproductive system is also treated with estrogen, it is important to find out whether it is carcinogenic. A large number of animal experiments show that mice with high natural incidence of tumor, feeding estrogen can increase the incidence of male tumor, but no effect on female rats.