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目的探讨2型糖尿病患者大血管并发症与DNA氧化损伤的关系。方法选择78例2型糖尿病患者,32例合并有大血管并发症(A组),46例无并发症(B组),检测患者的血三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、糖化血红蛋白(HbA1c)及8-羟基脱氧鸟嘌呤(8-OHdG)水平。8-OHdG检测采用酶联免疫吸附法。结果A组血8-OHdG水平(2.93±1.37)μg/L,B组(2.67±1.30)μg/L,2组比较无显著性差异;A组TG水平(1.99±0.98)mmol/L,明显高于B组的(1.54±0.89)mmol/L(P<0.05);A组病程(13.41±7.76)a,明显高于B组的(7.22±5.77)a(P<0.05)。血8-OHdG水平与病程、TG呈正相关关系,而与TC、LDL-C、HDL-C及HbA1c水平无明显相关关系。结论2型糖尿病患者大血管并发症的发生可能与高血糖所致氧化应激关系不大,而与血脂关系更密切;脂代谢异常是糖尿病氧化应激的重要影响因素。
Objective To investigate the relationship between macrovascular complications and DNA oxidative damage in type 2 diabetic patients. Methods 78 patients with type 2 diabetes mellitus, 32 patients with macrovascular complications (group A) and 46 patients without complications (group B) were enrolled in this study. Blood triglyceride (TG), cholesterol (TC), low density LDL-C, HDL-C, HbA1c and 8-OHdG. 8-OHdG detection using enzyme-linked immunosorbent assay. Results The level of blood 8-OHdG in group A was 2.93 ± 1.37 μg / L and in group B was 2.67 ± 1.30 μg / L, there was no significant difference between two groups. The TG level in group A was 1.99 ± 0.98 mmol / L, (1.54 ± 0.89) mmol / L in group B (P <0.05). The course of disease in group A (13.41 ± 7.76) a was significantly higher than that in group B (7.22 ± 5.77) a (P <0.05). Blood 8-OHdG levels and duration of disease, TG was positively correlated, but with no significant correlation between TC, LDL-C, HDL-C and HbA1c levels. Conclusions The occurrence of macrovascular complications in patients with type 2 diabetes may not be related to the oxidative stress induced by hyperglycemia, but closely related to the blood lipid. The abnormal lipid metabolism is an important factor in the oxidative stress of diabetes mellitus.