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本文报告在慢性乙型肝炎38例的外周血单核细胞(PBMC)和T、B淋巴细胞中检测到HBV标志物阳性29例(76.3％)。其中17例病人的PBMC中HBsAg,HBeAg和HBV-DNA阳性者分别为4,2和14例。21例病人分离出T,B淋巴细胞,其中T细胞中HBsAg,HBeAg与HBV-DNA阳性分别为2,2和1例;B细胞中分别为3,6,1例。血清HBV标志物阳性的病人其PBMC中这些标志物的检出率(13/15例)明显高于血清抗HBc和抗HBe阳性的稳定期病人(3/7例)。提示HBV可能感染和损害慢性乙型肝炎病人的淋巴细胞,这也许是乙型肝炎病人免疫功能异常的原因之一。
In this paper, 29 cases (76.3%) of HBV markers were detected positive in peripheral blood mononuclear cells (PBMCs) and T, B lymphocytes in 38 cases of chronic hepatitis B patients. Of the 17 patients, the positive rates of HBsAg, HBeAg and HBV-DNA in PBMC were 4, 2 and 14, respectively. T and B lymphocytes were isolated from 21 patients. Among them, the positive rates of HBsAg, HBeAg and HBV-DNA in T cells were 2, 2 and 1, respectively; in B cells, 3, 6 and 1, respectively. Serum HBV markers in patients with PBMC detection of these markers was significantly higher (13/15 cases) than serum anti-HBc and anti-HBe positive stable patients (3/7 cases). Suggesting that HBV may infect and damage lymphocytes of patients with chronic hepatitis B, which may be one of the reasons for the abnormal immune function of hepatitis B patients.