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目的研究测定膀胱肿瘤患者外周血粘附分子ＣＤ４４含量的改变及其在临床诊断和治疗中的意义。方法应用流式细胞免疫学方法，测定３０例膀胱肿瘤患者手术前后外周血粘附分子ＣＤ４４含量，并与健康组作对照。结果膀胱肿瘤患者术前外周血淋巴细胞ＣＤ４４含量（４６２８％±１７９４％）较正常对照组（４８３％±１７０％）显著增高（Ｐ＜００１），术后ＣＤ４４含量逐渐下降；在尚无症状和体征的原发及转移者（１９２２％±９５８％），与对照组比较也显著增高（Ｐ＜００５）。结论检测膀胱肿瘤患者外周血ＣＤ４４含量，对其早期诊断、早期发现复发和转移，都有重要的临床价值。
Objective To study the changes of peripheral blood adhesion molecule CD44 in patients with bladder cancer and its significance in clinical diagnosis and treatment. Methods Flow cytometry was used to determine the levels of CD44 in peripheral blood of 30 patients with bladder cancer before and after operation. The levels of CD44 were compared with those of healthy controls. Results The level of CD44 (4628% ± 1794%) in the peripheral blood lymphocytes in patients with bladder cancer before operation was significantly higher than that in the control group (4.83% ± 1.70%, P <001) The level of CD44 decreased gradually in patients with asymptomatic symptoms and signs of primary and metastasis (1922% ± 958%), compared with the control group was also significantly higher (P0.05). Conclusion Detection of CD44 in peripheral blood of patients with bladder cancer has important clinical value in early diagnosis and early detection of recurrence and metastasis.