以外消旋乳酸(D,L-LA)、乙二醇和二氯磷酸苯酯为原料,通过熔融聚合法直接合成生物降解材料聚磷酸酯-聚乳酸,用凝胶渗透色谱测定产物的相对分子质量,探讨了预聚方式、催化剂种类和用量,以及熔融聚合反应时间、反应温度对共聚物相对分子质量的影响。在160℃、70Pa、催化剂ZnO的用量0.5%的条件下熔融聚合8h,共聚物的重均分子量可达9200,可以用于药物缓释微球。新合成方法有利于降低聚磷酸酯-聚乳酸作为药物缓释载体材料的合成成本。 Poly (lactic acid) (PLA) - polylactic acid was synthesized directly by melt polymerization from racemic lactic acid (D, L-LA), ethylene glycol and phenyl dichlorophosphate. The relative molecular mass of the product was determined by gel permeation chromatography The effects of prepolymerization mode, catalyst type and amount, and the polymerization time and reaction temperature on the molecular weight of the copolymer were discussed. At 160 ℃, 70Pa, the amount of catalyst ZnO 0.5% under the conditions of melt polymerization 8h, the weight-average molecular weight of the copolymer up to 9200, can be used for drug delivery microspheres. The new synthesis method is conducive to reduce the synthesis cost of polyphosphate-polylactic acid as a drug sustained-release carrier material.