目的:分析了在我院就诊的妊娠期间甲状腺功能减退孕妇的临床资料,讨论妊娠合并甲状腺功能减退对妊娠结局的影响。方法:对在孕前明确诊断为妊娠合并甲状腺功能减退的孕妇,每个月监测离三碘甲状腺原氨酸(FL)、游离甲状腺索(FT4)、甲状腺刺激激素(TSH)浓度。当TSH值高于或合并FT4、FT4己值低于正常值或出现临床症状时,调整左旋甲状腺素,每次增加12.5pg;20例孕32周以后首次发现妊娠其甲状腺功能减退,未给予用药治疗;采用机械抽样法随机选取我院同期分娩的正常孕妇40例为对照组。结果:38例妊娠合并甲减治疗组,在孕前及整个孕期均进行甲功的监测和左旋甲状腺素的随访治疗,经治疗后该组的妊高症的发病仍高于对照组,差异有统计学意义(P<0.05);同样早产、低出生体重儿仍高于对照组,差异有统计学意义,但新生儿窒息率、新生儿畸形的发生率与对照组比较差异无统计学意义(P>O.05)。20例妊娠期甲减者未治疗孕妇,妊高症、早产、新生儿窒息、新生儿畸形的发生率均高于对照组。妊娠合并甲减治疗组和妊娠期甲减未治疗组相比,妊高征的发病差异无统计学意义,新生儿结局的发生率妊娠合并甲减治疗组明显低于妊娠期甲减组未治疗组。结论:重视对少数民族地区的早孕期甲状腺疾病筛查,尽量做到早发现、早干预,早期规范。 OBJECTIVE: To analyze the clinical data of pregnant women with hypothyroidism during pregnancy in our hospital and discuss the effect of pregnancy associated with hypothyroidism on pregnancy outcome. Methods: Pregnant women diagnosed with pre-pregnancy pregnancy complicated with hypothyroidism were monitored monthly for concentrations of triiodothyronine (FL), free thyroid cord (FT4) and thyroid stimulating hormone (TSH). When TSH value is higher than or combined with FT4, FT4 value is lower than normal or clinical symptoms, the adjustment of levothyroxine, an increase of 12.5pg; 20 cases of pregnancy for the first time after 32 weeks of hypothyroidism was found, did not give medication Treatment; 40 cases of normal pregnant women delivered at the same period in our hospital were randomly selected as the control group by mechanical sampling. Results: 38 cases of hypothyroidism with hypothyroidism treatment group before pregnancy and throughout the pregnancy were monitoring thyroid function and follow-up treatment of levothyroxine, after treatment, the incidence of pregnancy-induced hypertension is still higher than the control group, the difference was statistically significant (P <0.05). The same preterm, low birth weight infants still higher than the control group, the difference was statistically significant, but the neonatal asphyxia, the incidence of neonatal malformations compared with the control group was no significant difference (P > O.05). 20 cases of pregnant women with hypothyroidism untreated pregnant women, pregnancy-induced hypertension, premature birth, neonatal asphyxia, the incidence of neonatal malformations were higher than the control group. Pregnancy combined with hypothyroidism treatment group and pregnancy hypothyroidism untreated group, the incidence of PIH was no significant difference in the incidence of neonatal outcome in pregnancy with hypothyroidism treatment group was significantly lower than in pregnancy hypothyroidism untreated group. Conclusion: It is important to screen early stage thyroid disease in ethnic minority areas and try to find early, early intervention and early norms.