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目的:探讨心力衰竭患者血小板平均体积(MPV)的水平及其与B型钠尿肽(BNP)的相关性。方法:选取2013年10月到2015年10月入住南京鼓楼医院心内科的患者294例,分为非心力衰竭组(n-HF)92例、慢性心力衰竭组(CHF)69例、急性心力衰竭组(AHF)133例,回顾性分析其MPV、血小板计数(PLT)、BNP等数据。结果:AHF组BNP(1298.43±856.25 pg/m L)、CHF组BNP(198.54±118.72 pg/m L)均明显高于n-HF组(88.91±76.93 pg/m L)(P<0.05),且AHF组BNP显著高于CHF组(P<0.05);AHF组MPV(11.37±0.91 f L)与CHF组MPV(11.21±1.18 f L)均明显高于n-HF组(10.70±1.05 f L)(P<0.05),但AHF组与CHF组MPV相比没有统计学差异(P=0.532)。将AHF组与CHF组合并为心衰(HF)组,其BNP(922.72±920.55 pg/m L)及MPV(11.31±1.01 f L)明显高于n-HF组(P<0.05)。MPV与BNP的相关系数r=0.257,相关程度极弱。结论:心力衰竭患者MPV明显高于非心衰者,提示MPV水平可能有助于心力衰竭的诊断,但MPV与BNP基本不相关,且MPV在急性心力衰竭者与慢性心力衰竭者中没有差异。
Objective: To investigate the level of platelet mean volume (MPV) in patients with heart failure and its relationship with B-type natriuretic peptide (BNP). Methods: Totally 294 patients admitted to Nanjing Drum Tower Hospital from October 2013 to October 2015 were divided into non-heart failure group (n-HF), 92 cases, chronic heart failure group (CHF), 69 cases of acute heart failure Group (AHF) 133 cases, retrospective analysis of their MPV, platelet count (PLT), BNP and other data. Results: The levels of BNP (1298.43 ± 856.25 pg / m L) in AHF group and BNP (198.54 ± 118.72 pg / m L) in CHF group were significantly higher than those in n-HF group (88.91 ± 76.93 pg / m L) (P <0.05). The MPV in AHF group (11.37 ± 0.91 f L) and MPV in CHF group (11.21 ± 1.18 f L) were significantly higher than those in n-HF group (10.70 ± 1.05 f L ) (P <0.05). However, there was no significant difference between AHF group and CHF group (P = 0.532). The combination of AHF group and CHF combined with CHF group showed significantly higher BNP (922.72 ± 920.55 pg / m L) and MPV (11.31 ± 1.01 f L) than n-HF group (P <0.05). Correlation coefficient between MPV and BNP was 0.257, and the correlation was very weak. CONCLUSIONS: MPV in patients with heart failure is significantly higher than that in patients with non-heart failure, suggesting that MPV levels may contribute to the diagnosis of heart failure. However, MPV is not associated with BNP at all, and there is no difference in MPV among those with acute heart failure and chronic heart failure.