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目的分析葛根素注射液所致不良反应(ADR)的特点,为临床合理用药提供参考。方法检索中国学术期刊(网络版)、中国生物医学文献数据库(CBM)、万方数字化期刊全文库、中文科技期刊全文数据库(维普)等数据库报道的葛根素注射液致ADR的文献,并进行分析和讨论。结果葛根素注射液所致ADR男性明显多于女性,年龄多集中在50岁以上;心血管系统疾病患者的ADR最多,构成比为53.6%;绝大多数患者的给药剂量为400、500 mg/d,构成比分别为47.55%、26.57%;绝大多数患者(117例,62.23%)给药疗程为14 d;用药0.5~24 h的患者最多,占21.88%;ADR累及器官/系统以变态反应较为多见,构成比分别为14.36%。结论加强葛根素注射液ADR监测,确保患者临床用药安全有效。
Objective To analyze the characteristics of adverse reactions caused by puerarin injection (ADR) and provide reference for clinical rational drug use. Methods The literature of ADR induced by puerarin injection was searched in databases such as Chinese Academic Journal (Online), Chinese Biomedical Literature Database (CBM), Wanfang Digital Periodicals Full-text Database and Chinese Science Periodicals Full-text Database (VIP) And discussion. Results Puerarin injection resulted in significantly more ADR males than females, with age over 50 years of age; patients with cardiovascular diseases had the highest ADR with a ratio of 53.6%; the vast majority of patients were given doses of 400 and 500 mg / d, the constituent ratios were 47.55% and 26.57% respectively; the vast majority of patients (117 cases, 62.23%) were given medication for 14 days; those treated for 0.5-24 hours accounted for 21.88% Allergy is more common, the constituent ratios were 14.36%. Conclusion The ADR monitoring of puerarin injection should be strengthened to ensure the safety and effectiveness of clinical medication in patients.