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目的探讨聚束蛋白在基底细胞癌、鳞状细胞癌、乳腺外Paget病及黑色素瘤中的表达。方法用Elivision免疫组化法检测13例基底细胞癌、24例鳞状细胞癌、10例乳腺外Paget病、10例黑色素瘤以及10例正常皮肤组织中聚束蛋白的表达情况,分析聚束蛋白与皮肤肿瘤侵袭及转移的相关性。结果聚束蛋白在基底细胞癌、鳞状细胞癌表达显著高于正常上皮组织(P<0.05),聚束蛋白在黑色素瘤表达显著低于正常上皮组织(P<0.05)。结论聚束蛋白在基底细胞癌、鳞状细胞癌中高表达,提示可能与肿瘤的局部侵袭相关,聚束蛋白在黑色素瘤低表达,提示可能与肿瘤细胞在真皮内和机体内广泛播散相关。
Objective To investigate the expression of clusterin in basal cell carcinoma, squamous cell carcinoma, extramammary Paget’s disease and melanoma. Methods The expression of clusterin in 13 cases of basal cell carcinoma, 24 cases of squamous cell carcinoma, 10 cases of extrahepatic Paget’s disease, 10 cases of melanoma and 10 cases of normal skin tissue were detected by Elivision immunohistochemistry. Correlation with skin tumor invasion and metastasis. Results The expression of BOC in basal cell carcinoma and squamous cell carcinoma was significantly higher than that in normal epithelium (P <0.05). The expression of BOC in melanoma was significantly lower than that in normal epithelium (P <0.05). Conclusion The high expression of BOC in basal cell carcinoma and squamous cell carcinoma may be related to the local invasion of tumor. The low expression of BOC in melanoma may be related to the widespread dissemination of tumor cells in the dermis and in the body.