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目的 :研究毒品对男性NOR的rRNA基因活性的影响。方法 :采用Ag -NOR技术 ,分别对 30名男性吸毒患者和 30名正常男性的NOR及近端着丝粒染色体联合进行了初步研究。结果 :吸毒组与对照组的Ag -NOR和Ag -AA均呈随机分布 ;吸毒组的Ag -NOR频率低于对照组 ,差异显著 (P <0 0 5 ) ;两组之间的Ag -AA频率无显著性差异 (P >0 0 5 )。结论 :吸毒两年以上的男性患者表现出毒品对rRNA基因的活性有一定程度的抑制作用
Objective: To study the effect of drugs on the rRNA gene activity of male NOR. Methods: Ag-NOR technique was used to study the combination of NOR and paracancerous chromosomes in 30 male drug users and 30 normal males respectively. Results: Ag-NOR and Ag-AA in drug-induced and control groups were randomly distributed. The frequency of Ag-NOR in drug-treated group was lower than that in control group (P <0.05), and the Ag-AA There was no significant difference in frequency (P> 0.05). CONCLUSIONS: Male patients who had been on drug for more than two years showed that the drug inhibited the activity of rRNA gene to a certain degree