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目的:探讨恶性滋养细胞肿瘤(CNT)的治疗方法及效果。方法:回顾性分析41例恶性滋养细胞肿瘤(CNT)的临床资料。结果:有3例Ⅲ期患者入院急诊行双侧子宫动脉选择性插管化疗;单纯化疗22例,5-氟尿嘧啶(5-FU)+更生霉素(KSM),对于4例耐药及1例Ⅳ期患者用紫杉醇+铂类方案(TP方案)。7例辅以手术治疗,为围绝经期女性或耐药病例。39例患者达到满意的治疗效果。结论:恶性滋养细胞肿瘤的治疗应以化疗为主,对于子宫穿孔、阴道转移瘤、宫旁转移瘤及肝转移瘤等破裂所致大出血,动脉栓塞或动脉化疗栓塞为首选方式,使患者避免了手术及手术风险,保留了子宫,获得满意治疗。对于耐药患者必要时应辅以手术治疗,可以获得较好的疗效。
Objective: To investigate the treatment and effect of malignant trophoblastic tumor (CNT). Methods: A retrospective analysis of 41 cases of malignant trophoblastic tumor (CNT) clinical data. Results: There were 3 cases of stage Ⅲ patients admitted to hospital with bilateral uterine artery selective intubation chemotherapy; chemotherapy alone in 22 cases, 5-fluorouracil (5-FU) + dactinomycin (KSM), 4 cases of drug resistance and 1 case Ⅳ patients with paclitaxel + platinum plan (TP program). 7 cases supplemented by surgery for the perimenopausal women or resistant cases. 39 patients achieved satisfactory therapeutic effect. Conclusion: The treatment of malignant trophoblastic tumor should be based on chemotherapy. For patients with uterine perforation, vaginal metastasis, uterine metastasis and liver metastasis rupture caused by bleeding, arterial embolization or arterial chemoembolization as the preferred method to avoid patients Surgery and surgical risks, retained the uterus, access to satisfactory treatment. For patients with drug resistance should be supplemented with surgical treatment, you can get a better effect.