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检测１７０例原代乳腺癌细胞对常用化疗药物的体外敏感性。发现：①乳腺癌细胞对５－氟脲嘧啶（５－Ｆｕ），丝裂霉素Ｃ（ＭＭＣ），顺铂（ＤＤＰ）及泰素（ｔａｘｏｌ）的高度敏感率（ＨＳＲ）明显高于其它受试药物（Ｐ＜０．０５）；②药物敏感性与乳癌的病理分型和临床分期、以及雌激素受体（ＥＲ）和表皮生长因子受体（ＥＧＦＲ）表达状况无明显关系（Ｐ＞０．０５）；③环孢素Ａ（ＣｓＡ）能提高部分耐药乳腺癌对阿霉素（ＡＤＭ）的敏感性
The in vitro sensitivity of 170 primary breast cancer cells to commonly used chemotherapy drugs was examined. Findings: (1) The high sensitivity rate (HSR) of breast cancer cells to 5-fluorouracil (5-Fu), mitomycin C (MMC), cisplatin (DDP) and taxol (taxol) was significantly higher than that of other breast cancer cells. Test drug (P<0.05); 2 drug sensitivity and pathological type and clinical stage of breast cancer, and no significant relationship between estrogen receptor (ER) and epidermal growth factor receptor (EGFR) expression status (P>0 .05);3CsA can increase the sensitivity of partially resistant breast cancer to adriamycin (ADM)