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目的观察食管静脉曲张破裂出血行食管静脉曲张套扎术(EVL)后联合使用生长抑素对预防近期再出血的有效性。方法总结2001年10月至2010年10月因静脉曲张破裂引起上消化道大出血的病例174例,予内镜套扎治疗后,将使用生长抑素治疗病例设为观察组(68例),未使用生长抑素治疗病例设为对照组(106例),比较两组近期再出血的发生率。结果 174例食管静脉曲张破裂出血患者经内镜下套扎治疗后,观察组近期再出血率为22.06%,高于对照组近期再出血率(7.55%),两组比较差异有统计学意义(P<0.01)。结论 EVL预防再出血疗效较好,EVL联合使用生长抑素对预防近期再出血无优势,且生长抑素增加患者的医疗费用,对轻症病例不推荐使用。
Objective To observe the effectiveness of combined use of somatostatin in preventing esophageal variceal bleeding after esophageal variceal bleeding in patients with esophageal varices ligation. Methods A total of 174 cases of upper gastrointestinal hemorrhage due to rupture of varicose vein from October 2001 to October 2010 were summarized. After endoscopic ligation, the patients treated with somatostatin were enrolled in the observation group (68 cases) The treatment of somatostatin cases were used as the control group (106 cases), the incidence of recent rebleeding in both groups was compared. Results 174 cases of esophageal variceal bleeding in patients undergoing endoscopic ligation treatment, the observation group rebleeding rate was 22.06%, higher than the rate of recent rebleeding (7.55%), the difference between the two groups was statistically significant ( P <0.01). Conclusion EVL is effective in preventing rebleeding. EVL combined with somatostatin has no advantage in preventing recent rebleeding, and somatostatin increases the medical cost of patients and is not recommended for mild cases.