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盐酸利多卡因是一种广泛应用的局麻药,当静脉用药时,具有显著的多系统效应。静注利多卡因对听觉和前庭系统的影响已引起许多研究者的注意。曾有报导静注利多卡因可治疗耳鸣,改善听力;亦有用鼓膜穿刺注射此药的方法缓解美尼尔氏病患者耳鸣、眩晕等症状的成功实例。本研究的目的在于评价利多卡因静注对单侧迷路切除猫的眩晕控制效果。作者用体重2.5公斤左右的成年猫作为实验动物,观察切除猫的一侧迷路后及静脉注射利多卡因后动物的行为变化,并用眼震电图(ENG)记录眼震情况。对照组则静注等量的生理盐水。术后
Lidocaine hydrochloride is a widely used local anesthetic with significant multiple-system effects when administered intravenously. The effects of intravenous lidocaine on auditory and vestibular systems have attracted the attention of many researchers. It has been reported intravenous lidocaine tinnitus can be treated to improve hearing; also used tympanic membrane injection of this medicine method to alleviate the symptoms of tinnitus, dizziness and other successful cases of Meniere’s disease. The purpose of this study was to evaluate the dizziness control effect of lidocaine on unilateral labyrinthine cats. The author used an adult cat weighing about 2.5 kg as an experimental animal to observe the behavioral changes of the animals after labyrinthine injection of lidocaine and intravenous injection of lidocaine and record the condition of the nystagmus with an electrogram of the eye (ENG). The control group was intravenously injected with the same amount of saline. After surgery