论文部分内容阅读
6组小鼠分别饮含铅浓度为0、2、10、25、100和200mg/L的水3个月,以免疫细胞3H-TdR参入量为指标,观察其免疫功能的变化。结果表明,浓度10mg/L以上组脾淋巴细胞转化和浓度2mg/L以上组白细胞介素2诱生与对照组相比,降低非常显著(P<0.01)。并且,饮水铅浓度的增加与脾淋巴细胞转化和白细胞介素2诱生降低之间,存在剂量-效应关系,即y=14973—5811.7logx和y=23422.2—7845logx的指数曲线方程关系。提示,减少饮水铅污染,对提高人群免疫功能和预防疾病有一定意义。
Six groups of mice received water with lead concentrations of 0, 2, 10, 25, 100 and 200 mg / L for 3 months respectively. The changes of immune function were observed by 3H-TdR incorporation in immune cells. The results showed that the spleen lymphocyte transformation at a concentration above 10 mg / L and IL-2 induction at a concentration above 2 mg / L were significantly decreased compared with the control group (P <0.01). Also, there is a dose-response relationship between the increase in lead concentration in drinking water and the decrease in splenic lymphocyte transformation and interleukin-2 induction, ie, exponential curve equations for y = 14973-5811.7 logx and y = 23422.2-7845 logx . Tip, reduce lead pollution of drinking water, to improve the immune function of the population and prevent diseases have some significance.