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目的:研究血清同型半胱氨酸(Hcy)水平与中青年急性脑梗死的关系。方法:选择中青年急性脑梗死存活342例为急性脑梗死组(观察组),正常体检健康者40例为对照组。采用CT、MRI检查急性脑梗死不同部位和病灶大小,采用高效液相色谱荧光检测法测定两组血清Hcy水平并进行比较。结果:急性脑梗死责任病灶位于前循环215例,占62.9%;后循环127例,占37.1%。梗死病灶最大直径≤2cm者86例,占25.1%;2～5cm者167例,占48.8%;>5cm者89例,占26.1%。观察组血清Hcy水平非常显著高于对照组(P<0.01)。观察组治疗后血清Hcy水平非常显著低于治疗前(P<0.01)。结论:血清Hcy高水平是中青年脑梗死发生和复发的危险因素之一,药物治疗可降低Hcy水平。
Objective: To study the relationship between serum homocysteine (Hcy) levels and acute cerebral infarction in middle-aged and young adults. Methods: 342 young and middle-aged patients with acute cerebral infarction were selected as the acute cerebral infarction group (observation group) and 40 healthy controls were selected as the control group. The CT and MRI were used to examine the different parts of the acute cerebral infarction and the size of the lesion. The levels of Hcy in the two groups were measured by high performance liquid chromatography (fluorescence) detection and compared. Results: Responsible lesions of acute cerebral infarction located in the anterior circulation of 215 cases, accounting for 62.9%; 127 cases of post-circulation, accounting for 37.1%. There were 86 cases (25.1%) with the largest diameter of infarction ≤2 cm, 167 cases (range 2 ~ 5 cm), accounting for 48.8%. 89 cases> 5 cm, accounting for 26.1%. The level of Hcy in observation group was significantly higher than that in control group (P <0.01). The level of Hcy in the observation group after treatment was significantly lower than before treatment (P <0.01). Conclusion: The high level of serum Hcy is one of the risk factors for the occurrence and recurrence of middle-aged and young cerebral infarction. Drug treatment can reduce the level of Hcy.