碳酸氢钠注射液处方和制备工艺虽简单,但其澄明度确是一道难关,其影响澄明度的杂质主要是雾状微粒、小白点、小自块。经分析杂质成分绝大部分是碳酸钙,碳酸镁。因此,要解决碳酸氢钠注射液澄明度问题,须从除去难溶性碳酸盐着手。鉴于上述情况,应用溶度积原理对碳酸氢钠注射液的制备 Sodium bicarbonate injection formulation and preparation process is simple, but its clarity is indeed a difficult one, its impact on the clarity of the impurities are mainly fog particles, white spots, small self-block. The analysis of impurities is the vast majority of calcium carbonate, magnesium carbonate. Therefore, to solve the clarity of sodium bicarbonate injection, start with the removal of insoluble carbonates. In view of the above, the application of solubility product principle of sodium bicarbonate injection preparation