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硫糖铝为蔗糖硫酸酯的碱式铝盐,能减少胃蛋白酶分解蛋白的活性,与胃粘膜蛋白形成保护膜,促进粘膜增生等多方面作用,治疗胃溃疡有良好的疗效。但它对肠溃疡无明显疗效或甚至无效,那是由于空腹服用硫糖铝后,先进入胃中,硫糖铝即与胃粘膜形成保护膜,胃的容积相当大,服下的有限的硫糖铝已大部留在胃壁上,进入肠的仅是少量或甚至已没有了。所以一般的硫糖铝片对肠溃疡没有多大作用。为了要使硫糖铝在肠中发挥作用,我们将硫糖铝做成肠溶胶囊,就是在胶囊外包有一层肠膜,在酸性的胃液中不溶解,在碱性的肠液中即迅速崩解。因此,当服用这种肠溶胶囊后,能够
Sucralfate is a basic aluminum salt of sucrose sulphate, which can reduce the activity of pepsin protein, form a protective film with gastric mucosal protein and promote mucosal hyperplasia, and has good curative effect in treating gastric ulcer. But it has no significant effect on intestinal ulcer or even ineffective, which is due to fasting after taking sucralfate, first into the stomach, sucralfate and gastric mucosa to form a protective film, the stomach volume is quite large, taking the limited sulfur Most of the sugar and aluminum have been left in the stomach wall, enter the intestine only a small amount or even no longer. So the general sucralfate on intestinal ulcer is not much effect. In order to make sucralfate play a role in the intestine, we make sucralfate enteric-coated capsules, that is, the capsule is covered with a layer of intestinal membrane, insoluble in acidic gastric juice, rapidly disintegrating in alkaline intestinal juice . Therefore, when taking this enteric-coated capsules, can