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在我们以往的实验研究中,用生理学或药理学方法破坏或减弱大白鼠脑内5-羟色胺(5-HT)能神经元系统的神经传递(损毁中脑中缝核群,注射5-HT 合成抑制剂对氯苯丙氨酸),唇针的镇痛效应减弱;相反,激活或加强这个系统的神经传递(刺激中缝背核,脑室注射5-HT),则唇针的镇痛效应增强。此外,能够提高脑内5-HT 含量的药物(胰岛素和氨茶碱),也能提高大白鼠唇针的镇痛效应。这些实验资料充分证明,象其他
In our previous experimental studies, neurophysiological or pharmacological methods were used to disrupt or attenuate neurotransmission of serotonergic (5-HT) neuronal systems in the rat brain (damage to the midbrain karyokal nuclei, suppression of 5-HT synthesis by injection (P-chlorophenylalanine), the analgesic effect of the lip was weakened; on the contrary, the activation or strengthening of the system of neurotransmission (stimulation of the dorsal raphe nucleus, intraventricular injection of 5-HT), the lip acupuncture analgesic effect increased. In addition, drugs that increase 5-HT levels in the brain (insulin and aminophylline) also increase the analgesic effect of the labial needles of rats. These experimental data fully prove, like other