论文部分内容阅读
实验在40只麻醉、制动、断双侧颈迷走神经和人工通气的家兔上进行。在孤束核腹外侧区微量注射神经元胞体兴奋剂谷氨酸钠和抑制剂甘氨酸,探讨膈神经放电的变化。结果:微量注射谷氨酸钠,可使膈神经放电脉冲数明显增加,吸气时程延长,呼气时程缩短,呼吸频率变化不明显;微量注射甘氨酸,则膈神经放电脉冲数显著减少,甚至停止,吸气时程缩短,呼气时程不规则延长,呼吸频率降低。上述结果提示:孤束核腹外测区对呼吸节律的形成具有重要的影响。
The experiment was performed on 40 rabbits anesthetized, braked, severed bilateral vagus nerves and artificially ventilated. Microinjection of glutamate and glycine, a stimulator of neuronal somatotropin, into the ventrolateral part of the nucleus tractus solitarius was performed to investigate the changes of phrenic nerve discharge. Results: Micro-injection of sodium glutamate increased the number of pulses of phrenic nerve discharge, prolonged inspiratory time, shortened expiratory time and no obvious change of respiratory rate. When microinjection of glycine, the number of phrenic nerve discharge pulses decreased significantly, Or even stop, shorten the inspiratory process, irregular expiratory duration, lower respiratory rate. The above results suggest that the solitary nuclear measurement zone has an important impact on the formation of respiratory rhythm.