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重型病毒性肝炎是病毒性肝炎中预后差、病死率高的一种类型。近年来病死率仍在60％以上。目前许多学者在综合疗法的基础上,针对肝细胞再生、抗病毒等方面不断进行研究,取得进展,提高了治愈率。笔者复习部分文献综述如下。 1 肝细胞生长素应用 肝细胞生长素是从乳猪新鲜肝脏提取的小分子量多肽类活性物质,均分子量为10685D,重分子量为11350D。主要机理:①刺激肝细胞合成DNA,促进肝细胞修复和再生。②提高枯否氏细胞功能,降低循环内毒素水平。③抑制内毒素对肿瘤坏死因子的诱生作用。④抗纤维化作用。⑤其他作用。有报道肝细胞生长素可提高血清雌二醇水平,增加氨基酸的摄取,有利于促进肝细胞生长。董祥家等报道[3]:用肝细胞生长素治疗重型病毒性肝炎在降低血清总
Severe viral hepatitis is a poor prognosis in viral hepatitis, high mortality of a type. In recent years, the case fatality rate is still above 60%. At present, many scholars on the basis of comprehensive treatment, for liver regeneration, antiviral and other aspects of continuous research, progress and improve the cure rate. The author review part of the literature is summarized as follows. Application of hepatocyte growth hormone Hepatocyte growth factor is a small molecular weight polypeptide active substance extracted from the fresh liver of suckling pig with the average molecular weight of 10685D and the molecular weight of 11350D. The main mechanism: ① stimulate liver cells synthesize DNA, promote liver cell repair and regeneration. ② improve the function of Kupffer cells, reduce circulating endotoxin levels. ③ inhibit endotoxin induced tumor necrosis factor. ④ anti-fibrosis effect. ⑤ other role. It has been reported that hepatocyte growth hormone can increase serum estradiol levels, increase amino acid intake, is conducive to promoting liver cell growth. Dong Xiangjia other reports [3]: hepatocyte growth hormone treatment of severe viral hepatitis in reducing serum total