论文部分内容阅读
目的了解炎症标记物超敏C反应蛋白(hsCRP)与老年高血压患者颈动脉粥样硬化发生之间的关系,进一步加深对高血压导致外周血管病变的认识。方法对入选154例老年高血压患者进行颈动脉超声测量颈动脉内中膜厚度(IMT)、观察有无斑块形成,定量检测血清hsCRP,并进行血清hsCRP与颈动脉内中膜增厚、斑块(颈动脉粥样硬化)之间的相关性分析。结果合并颈动脉粥样硬化的高血压患者血清hsCRP明显高于无颈动脉硬化患者[(4.94±4.76)vs(3.12±3.90)mg/L,P<0.05]。有颈动脉斑块的患者血清hsCRP显著高于颈动脉内中膜正常与增厚患者,分别为(5.38±4.96)vs(3.12±3.90)mg/L,(5.38±4.96)vs(3.55±3.81)mg/L,P<0.05。结论血清hsCRP水平与高血压患者颈动脉粥样硬化的发生有一定相关性,合并颈动脉粥样硬化尤其有颈动脉斑块的患者血清hsCRP显著高于无颈动脉病变患者。
Objective To understand the relationship between inflammatory markers hsCRP and carotid atherosclerosis in elderly patients with hypertension and further deepen the understanding of hypertension-induced peripheral vascular disease. Methods The carotid artery intima-media thickness (IMT) was measured by carotid ultrasonography in 154 elderly hypertensive patients. The plaque formation was observed. Serum hsCRP was quantitatively measured. Serum hsCRP and carotid intima-media thickness Correlation analysis of blocks (carotid atherosclerosis). Results The serum hsCRP in patients with carotid atherosclerosis was significantly higher than that in patients without carotid atherosclerosis [(4.94 ± 4.76) vs (3.12 ± 3.90) mg / L, P <0.05]. The serum hsCRP levels in patients with carotid artery plaque were significantly higher than those in carotid artery intima-media thickness and normal patients (5.38 ± 4.96 vs 3.12 ± 3.90 mg / L, 5.38 ± 4.96 vs 3.55 ± 3.81, ) mg / L, P <0.05. Conclusion The serum hsCRP level is correlated with the occurrence of carotid atherosclerosis in patients with hypertension. The serum hsCRP levels in patients with carotid atherosclerosis, especially carotid plaque, are significantly higher than those without carotid artery disease.