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目的探讨妊娠期糖尿病(GDM)孕妇谷氨酸脱羧酶自身抗体(GADA)分布情况及GADA阳性是否为影响胎儿发育及妊娠结局的危险因素。方法2004年1～9月广州市妇婴医院无糖尿病史的孕妇中,随机选择GDM孕妇93例作为研究组,30例50g糖筛查正常的孕妇作为对照组,用酶联免疫法测定GADA并分析各组孕妇临床特征、胎儿发育、妊娠结局和产后血糖情况。结果GDM组中GADA阳性率38.7%,高于正常对照组。GDM孕妇中GADA阳性的患者体重指数(BMI)较低,妊娠失败率较高,更可能分娩体重过大或过小新生儿。结论GDM孕妇中混有一些亚临床状态的1型糖尿病患者,GADA阳性可能为GDM孕妇严重高危因素,GADA阳性产妇产后应加强随访。
Objective To investigate the distribution of glutamic acid decarboxylase autoantibodies (GADA) in pregnant women with gestational diabetes mellitus (GDM) and whether GADA positive is the risk factor for fetal development and pregnancy outcomes. Methods From January to September 2004, Guangzhou Women and Babies Hospital, a non-diabetic pregnant women, randomly selected 93 cases of GDM pregnant women as study group, 30 cases of 50g sugar screening normal pregnant women as a control group, GADA was determined by enzyme-linked immunosorbent assay The clinical characteristics, fetal development, pregnancy outcome and postpartum blood glucose were analyzed in each group. Results The positive rate of GADA in GDM group was 38.7%, higher than that in normal control group. GDM-positive pregnant women with GDM lower body mass index (BMI), pregnancy failure rate is higher, more likely to give birth weight or too small newborn. Conclusion GDM pregnant women with some sub-clinical type 1 diabetes, GADA positive may be serious risk factors for GDM pregnant women, GADA positive maternal postpartum should be strengthened follow-up.