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目的观察5-羟色胺/去甲肾上腺素再摄取抑制剂度洛西汀治疗抑郁症伴发糖尿病的疗效及不良反应。方法用该药治疗抑郁症伴发糖尿病30例。进行2、4和8周的观察,度洛西汀30～60mg/d,用汉密尔顿抑郁量表(HAMD)评定疗效,药物副反应量表(TESS)评定药物不良反应。空腹和餐后2小时血糖用于血糖控制的监测。结果完成治疗后,病人的HAMD总分显著下降,均达到统计学意义(t=2.66,2.77,2.81;P<0.01),显效率为63%。不良反应轻微(r=-0.33,P>0.05),无1例因药物不良反应导致治疗中断。结论度洛西汀治疗抑郁症伴发糖尿病患者的抑郁症状有效,安全。
Objective To observe the efficacy and adverse reactions of duloxetine, a serotonin / norepinephrine reuptake inhibitor, in the treatment of depression with diabetes. Methods The drug used in the treatment of 30 cases of depression associated with diabetes. After 2,4 and 8 weeks of observation, duloxetine 30 ~ 60mg / d, with the Hamilton Depression Scale (HAMD) to assess the efficacy of drug side effects scale (TESS) to assess adverse drug reactions. Fasting and 2 hours postprandial blood glucose are used for the monitoring of glycemic control. Results After the treatment, the total score of HAMD in patients decreased significantly, reaching statistical significance (t = 2.66,2.77,2.81; P <0.01), and the effective rate was 63%. Adverse reactions were mild (r = -0.33, P> 0.05), no one due to adverse drug reactions lead to treatment interruption. Conclusion Duloxetine is effective and safe in treating depression in patients with depression and diabetes.