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Background and Objective:Expression of Skp2 was related with the prognosis of several tumors.However,there was no intensive study on the relationship between Skp2 and extranodal NK/T-cell lymphoma.This study was to explore the role of Skp2 in extranodal NK/T-cell lymphoma.Methods:The clinicopathological data of 39 patients with extranodal NK/T-cell lymphoma were analyzed.The expression of Skp2 was examined by immunohistochemistry on formalin-fixed,paraffin-embedded tissue sections.Results:Among the patients with high expression of Skp2,complete remission(CR) rate was only 14.3%(2/14).However,CR rate among the patients with low expression of Skp2 was 68.0%(17/25).Significant difference was shown between these two groups(P < 0.001).In the group of low expression,the median overall survival(OS) was 85.59 months(95% CI:35.83-135.34 months),the 1-and 2-year OS rates were 81% and 71%,respectively.However,in the group of high expression,the median OS was only 9.73 months(95% CI:2.05-17.40 months),the 1-and 2-year OS rates were 42% and 14%,respectively.There was statistical difference between these two groups(P < 0.001).Multivariate analysis showed that Skp2 expression(P <0.001),LDH(P = 0.026) and ECOG PS(P = 0.003) were dependent prognostic factors of extranodal NK/T-cell lymphoma.Conclusion:High expression of Skp2 is an independent unfavorite adverse prognostic factor of extranodal NK/T-cell lymphoma.
Background and Objective: Expression of Skp2 was related with the prognosis of several tumors. Despite, there was no intensive study on the relationship between Skp2 and extranodal NK / T-cell lymphoma. This study was to explore the role of Skp2 in extranodal NK / T-cell lymphoma. Methods: The clinicopathological data of 39 patients with extranodal NK / T-cell lymphoma were analyzed. The expression of Skp2 was examined by immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections. Results: Among the patients with high Expression of Skp2, complete remission (CR) rate was only 14.3% (2/14) .Wowever, CR rate among the patients with low expression of Skp2 was 68.0% (17/25) .Significant difference was shown between these two groups ( In the group of low expression, the median overall survival (OS) was 85.59 months (95% CI: 35.83-135.34 months), the 1-and 2-year OS rates were 81% and 71% .Wever, in the group of high expression, the median OS was only 9.73 months (95% CI: 2.05-17.40 mon Ths), the 1-and 2-year OS rates were 42% and 14%, respectively. Statistical differences between these two groups (P <0.001) .Multivariate analysis showed that Skp2 expression (P <0.001) = 0.026) and ECOG PS (P = 0.003) were dependent prognostic factors of extranodal NK / T-cell lymphoma. Confluence: High expression of Skp2 is an unfied unfavorite adverse prognostic factor of extranodal NK / T-cell lymphoma.