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目的探讨白细胞介素(IL)-5在青霉素过敏反应中作用及其与IgE和IgG的关系。方法采用酶联免疫吸附试验(ELISA)测定了47例青霉素过敏病人(速发型、迟发型过敏反应病人分别为36例和11例)血清中的IL-5。采用放射过敏原吸附试验(RAST)、ELISA测定34例病人血清中的9种特异性IgE、总IgE和2种特异性IgG。结果青霉素过敏病人血清中IL-5水平显著高于对照组(P<0.05)。速发型和迟发型青霉素过敏病人血清中IL-5水平均显著高于对照组(P<0.05)。特异性IgE抗体阴性的青霉素过敏病人血清中IL-5与多种特异性IgE抗体呈负相关(P<0.05)。青霉素过敏病人血清中IL-5与总IgE、特异性IgG无明显相关性(P>0.05)。结论IL-5在青霉素过敏反应中起重要作用。
Objective To investigate the role of interleukin (IL) -5 in penicillin hypersensitivity and its relationship with IgE and IgG. Methods Serum levels of IL-5 in 47 patients with allergic reactions to penicillin (immediate and delayed-type hypersensitivity reactions were 36 and 11, respectively) were determined by enzyme-linked immunosorbent assay (ELISA). Radioimmunoassay (RAST) was used to detect nine kinds of specific IgE, total IgE and two kinds of specific IgG in sera of 34 patients by ELISA. Results Serum levels of IL-5 in patients with penicillin allergy were significantly higher than those in the control group (P <0.05). The levels of IL-5 in sera of patients with immediate-onset and late-onset penicillin allergy were significantly higher than those of the control group (P <0.05). IL-5 in serum of patients with specific IgE-negative penicillin allergy was negatively correlated with multiple specific IgE antibodies (P <0.05). There was no significant correlation between serum IL-5 and total IgE and specific IgG in patients with penicillin allergy (P> 0.05). Conclusion IL-5 plays an important role in the allergic reaction of penicillin.