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作为负反馈调节因子,microRNA-146a的异常表达以及调控诱导Th17细胞分化,参与了原发性干燥综合征的发生、发展过程,microRNA-146a作为一种新型生物标志物有重要临床应用价值。本文就microRNA-146a与干燥综合征研究进展作一综述。
As a negative feedback regulator, the abnormal expression of microRNA-146a and the regulation of Th17 cell differentiation are involved in the pathogenesis and progression of Sjogren’s syndrome. As a new biomarker, microRNA-146a has important clinical value. This article reviews the progress of microRNA-146a and Sjogren’s syndrome.