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1954年作者首次报告了类固醇性青光眼,并认为,眼压升高与前房角粘多糖的存在有关。作者等(1974)证明,在前房角各种结构中存在着不溶性酸性粘多糖。通过对兔的实验研究,现已进一步了解皮质类固醇性青光眼的发病机理。粘多糖对于眼内压的调节是很重要的。正常时,动物和人的角巩膜小梁中存在着酸性粘多糖或透明质酸。在巩膜静脉窦内壁处较丰富。正象其它成纤维组织一样,也存在着前房角细胞克隆(clones of gonioeytes),源出于相同母细胞,基因相同。一定数量的前房角细胞克隆可生成高浓度的粘多糖。这些酸性粘多糖可被转运入基质而与胶原结合,成为不溶性物质;组织化学阳性反应据此可
In 1954, the authors first reported steroid-induced glaucoma and concluded that elevated intraocular pressure is associated with the presence of amylopectin in the anterior chamber. The authors (1974) demonstrated that insoluble acid mucopolysaccharides exist in various structures of the anterior chamber horn. Through the experimental study of rabbits, we have further understand the pathogenesis of corticosteroid-induced glaucoma. Mucopolysaccharidoses are important for the regulation of intraocular pressure. Normally, acidic mucopolysaccharides or hyaluronic acid are present in the scleral tracts of animals and humans. In the scleral sinus wall at the more abundant. Just like other fibroblasts, there are also clones of gonioeytes, which are derived from the same blast cell and have the same gene. A number of anterior chamber angle cell clones produce high concentrations of mucopolysaccharides. These acidic mucopolysaccharides can be transported into the matrix and combined with the collagen into insoluble material; histochemical positive reaction accordingly