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目的分析垂体泌乳素腺瘤性原发性闭经的临床特点并评价其治疗效果。方法回顾性分析我院1995～2000年收治的5例垂体泌乳素腺瘤引起的原发性闭经患者的临床资料。结果根据肿瘤类型及生长方向分别行经颅或经蝶入路手术,5例垂体瘤次全切除3例(侵蚀型),全切除2例(局限型)。所有患者视力障碍均明显改善,血清PRL水平有不同程度下降,但只有1例患者在术后辅以溴隐亭治疗时有药物依赖性月经。结论此型垂体泌乳素腺瘤侵袭性强,手术治愈率低,术后辅以溴隐亭治疗可提高疗效,增加治愈机会。
Objective To analyze the clinical features of pituitary prolactinoma primary amenorrhea and evaluate its therapeutic effect. Methods The clinical data of 5 patients with primary amenorrhea induced by pituitary prolactinomas in our hospital from 1995 to 2000 were retrospectively analyzed. Results According to the type of tumor and the direction of growth, transcranial or transsphenoidal surgery was performed respectively. Subtotal excision was performed in 5 cases of pituitary adenomas (erosive type) and 2 cases of partial resection (localized type). All patients with visual impairment were significantly improved serum levels of PRL decreased to varying degrees, but only one patient supplemented with bromocriptine after treatment with drug-dependent menstruation. Conclusions This type of pituitary prolactinoma is highly invasive and has a low cure rate. Postoperative bromocriptine treatment can improve the curative effect and increase the chance of cure.