为及时、有效地诊治丙烯酰胺中毒提供依据,收集临床住院和国内外文献报道的经皮肤和呼吸道吸收丙烯酰胺所致急性中毒与口服中毒病例,并对其临床发病特点、口服丙烯酰胺剂量、发病潜伏期、首发症状及病程特点、治疗恢复情况等进行总结。结果显示,急性丙烯酰胺中毒早期症状以共济失调、意识障碍和皮肤表现如多汗、红斑、脱皮为主,分别占85.7%、71.4%和57.1%,口服中毒者以胃肠道和中枢神经系统功能障碍症状为主,分别占56.5%和30.4%,急性丙烯酰胺中毒在急性期过后会出现周围神经损伤表现,经及时治疗有不同程度恢复。提示,经皮肤与呼吸道吸收所致急性丙烯酰胺中毒和口服中毒的特点与慢性中毒不同,早期及时治疗是抢救成功、减少并发症的关键。 To provide a basis for timely and effective diagnosis and treatment of acrylamide poisoning, to collect clinical inpatients and domestic and foreign literature reported by the skin and respiratory tract absorption of acrylamide acute poisoning and oral poisoning cases, and its clinical features, oral dose of acrylamide, incidence Latency, initial symptoms and course of disease characteristics, treatment and recovery were summarized. The results showed that the early symptoms of acute acrylamide poisoning were ataxia, disturbance of consciousness and skin manifestations such as hyperhidrosis, erythema and dermabrasion, accounting for 85.7%, 71.4% and 57.1% respectively. Oral poisoning occurred mainly in the gastrointestinal tract and central nervous system Symptoms were the main symptoms of dysfunction, accounting for 56.5% and 30.4% respectively. Acute acrylamide poisoning showed peripheral nerve injury after acute phase and recovered in different time after treatment. Prompted by the skin and respiratory absorption caused by acute acrylamide poisoning and oral toxicity and chronic poisoning is different from the early timely treatment is the key to successful rescue and reduce complications.