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[目的] 观察安胃汤对慢性萎缩性胃炎胃肠激素的影响。[方法] 用N 甲基 N’ 硝基 N 亚硝基胍制作慢性萎缩性胃炎的动物模型。放射免疫法检测血胃泌素(GAS)、胃动素(MOT)和胃黏膜生长抑素(SS)水平。[结果] 与模型组相比,安胃汤增加大鼠血GAS和胃黏膜 SS水平,降低血 MOT水平(P<0.05,<0.01)。安胃汤能修复和保护胃黏膜。[结论] 调节胃肠激素水平可能是安胃汤治疗慢性萎缩性胃炎的机制之一。
[Objective] To observe the effect of Anwei Decoction on gastrointestinal hormones in chronic atrophic gastritis. [Methods] An animal model of chronic atrophic gastritis was made using N-methyl N’nitronitroso nitrosoguanidine. Radioimmunoassay detected blood gastrin (GAS), motilin (MOT) and gastric mucosal somatostatin (SS) levels. [Results] Compared with the model group, Anwei Decoction increased blood GAS and gastric mucosa SS levels, and reduced blood MOT levels (P<0.05, <0.01). Anwei soup can repair and protect the gastric mucosa. [Conclusion] Regulating gastrointestinal hormones may be one of the mechanisms of Anwei Decoction in treating chronic atrophic gastritis.